Centro Hospitalar Universitário de Santo António

Metabolomic analysis and urinary proteomics - reference to our translational research unit from the University of Porto - Unit for Multidisciplinary Research in Biomedicine/ School of Medice and Biomedical Sciences (https://umib.icbas.up.pt/)/ School of Medicine and Biomedical Sciences (ICBAS) University of Porto.

Mass spectrometry - in-house; 2026 we will be equiped with laser capture microdissection

For Heart Transplant programme - reference to ULS Coimbra, Portugal
Stem cell transplant - IPO-Porto/ Instituto Português de Oncologia, Porto, Portugal

Although tested and typed we do not have diagnostics of AApo's and ALECT2.
Our Center, Centro Hospitalar Universitário de Santo António/Unidade de Saúde Local de Saúde de Santo António has a clinical team of specialists/experts/interprofessional team and reseachers working closely with a collaborative support to all types of amyloidosis.

The Department of Nephrology has expertise in systemic and localized amyloidosis; Kidney Transplantation Unit, living donor programme and outpatient clinics (secretariadoce.nefrologia@ulssa.min-saude.pt).

Clinical Medicine Specialities:
- Nephrology, Hematology and Cardiology: Ward and Day Hospital
- Clinical Immunology Unit for autoinflammatory and autoimmune diseases: Day Hospital
- Liver Transplant Unit: Ward, outpatient clinics.

ATTRv - the most common type of amyloidosis at ULS de Santo António (ULSSA).
The clinical support is centralized in the Amyloid Unit/ Unidade Corino de Andrade being Neurology the main medical speciality for reference, supported by the Department of Neurophysiology and the Unit of Neuropathology.
The Unit has a multidisciplinary team and specialities closely coordinated.

The Hospital (on-site) has a Department of Ophtalmology with a wide ATTR expertise.
Nephrology (www.ulssa.pt/v0C0J0D0O/servico-de-nefrologia) supports chronic kidney disease, systemic complications and cardio-kidney-metabolic disease.
The Department of Cardiology (www.ulssa.pt/v0C0J0D0K/servico-de-cardiologia) gives support to rhythm disorders, pacemaker insertion and heart failure.
Nutritional dedicated support, Physical and Rehabilitation Medicine, Psychological and Phsychiatry and dedicated Dermatology.
Nurse Coordination Care and Patient Education.

Day Hospital for ATTRv therapy.
Organization of Clinical Trials in connection with Clinical Academic Centre (https://cacicbas.ulssa.pt/v0B0A/unidade-de-ensaios-clinicos).

The Hospital (on-site) has a Liver and Pancreas Transplantation Unit with multiorgan transplantation offer.

Nuclear Medicine and Imagiology Department (www.ulssa.pt/v0C0J0G/clin-de-imagiologia-diagnostica-e-de-intervencao).
Department of Anatomic Pathology, Pathology, Medical Genetics and Laboratorial Genetics - support for diagnosis.

Genetic/hereditary amyloidosis: AGel, ATTR, AFib, Apolipoprotein A-I (AApoA1) and AApoA2, ALys - on-site diagnosis (genetics and IHQ)
Autoinflammatory Gene Panel and AA- on-site diagnosis;
Leukocyte chemotactic factor 2 (ALECT2) - IHQ

Neuropathology (www.ulssa.pt/v0C0J0E0B/servico-de-neuropatologia) and Portuguese Brain Bank (www.ulssa.pt/v0I0D/banco-de-cerebros)

Metabolomic analysis and urinary proteomics - research unit from the University of Porto - Unit for Multidisciplinary Research in Biomedicine/ School of Medice and Biomedical Sciences

Services associated to:
- European Rare Diseases Networks - ERKNet, ERN-RITA, ReCONNET, EuroBloodNet, ERN EURO-NMD;
- National Reference Centers associated to amyloid diseases – Paramiloidose, Kidney Transplantation Adults and Pediatrics, Liver Transplantation Adults, Cystic Fibrosis, Hereditary Metabolic Diseases

ATTRv patient association: https://paramiloidose.com